need to find low dose to reboot the system
Sirolimus , Rapacan, Siromus, Rapamune
5 mg.kg-1.day-1, N = 9
https://www.1mg.com/generics/sirolimus-210691
Effect of oral rapamycin (treated) for 12 weeks on atherosclerotic plaque formation in apolipoprotein E-deficient mice compared to untreated (control) mice. Typical photomicrographs, at low (40X) and high (100 to 400X) magnification, are from aortic root sections stained with oil-red-O to visualize lipid-rich lesions and counterstained with hematoxylin-eosin. Histogram shows the average lipid deposition area in aortic root sections. Data are reported as means ± SEM. *P < 0.05 vs control group (Student t-test).
Plaque-Specific Adhesive Balloons Coated with Calcium Phosphate Nanoparticles Loaded with Rapamycin for Atherosclerosis Therapy
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202315317
Beneficial effects of rapamycin on endothelial function in systemic lupus erythematosus
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1446836/full
Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
https://pmc.ncbi.nlm.nih.gov/articles/PMC2697718
Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
https://www.scielo.br/j/bjmbr/a/g7cCJJ6VwqQqWPG7ZXjhXpH/?lang=en
Rapamycin reduces atherosclerotic plaque inflammation in aged mice
https://academic.oup.com/cardiovascres/article/120/Supplement_1/cvae088.204/7684113
Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway
Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27Kip1-independent pathway
https://www.sciencedirect.com/science/article/abs/pii/S0021915003003964
Targeted delivery of rapamycin and inhibition of platelet adhesion with multifunctional peptide nanoparticles for atherosclerosis treatment
https://www.sciencedirect.com/science/article/abs/pii/S0168365924007247
Rapamycin: A Bacteria-Derived Immunosuppressant That Has Anti-atherosclerotic Effects and Its Clinical Application
https://pmc.ncbi.nlm.nih.gov/articles/PMC6330346
Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
https://pmc.ncbi.nlm.nih.gov/articles/PMC2697718
Combined application of rapamycin and atorvastatin improves lipid metabolism in apolipoprotein E-deficient mice with chronic kidney disease